Aaron J. Rossini

Assistant Professor [CHEM]

Contact

Dept:Chemistry
Office:0205 Hach
2438 Pammel Dr
Ames IA
50011-1079
Phone:515-294-8952

Topics of interest: Characterization, Materials, Nuclear Magnetic Resonance, Pharmaceuticals, Solid-state NMR, Spectroscopy

Bio

Our research centers on the development and application of solid-state nuclear magnetic resonance (NMR) spectroscopy for the characterization of materials and pharmaceuticals. In particular, we use state of the art high field dynamic nuclear polarization (DNP) to enhance the sensitivity of solid-state NMR experiments by several orders of magnitude. This enables application of NMR to previously inaccessible systems and can dramatically improve structure elucidation. Researchers in my group will primarily work with NMR spectroscopy, however, they also gain experience in other characterization and modeling techniques such as EPR spectroscopy, quantum chemical calculations, X-ray diffraction, and other characterization techniques.

Peer-Reviewed Articles (55)

Research Interests

The comprehensive atomic level characterization of systems such as heterogeneous catalysts, pharmaceuticals, nanoparticles, functional materials, etc. often presents a considerable challenge due to disorder and/or dilution of the species of interest. Research in our group centers on utilizing solid-state NMR to investigate the structure and composition of systems that are challenging to characterize with conventional techniques. In particular, we will explore the development and application of dynamic nuclear polarization (DNP) enhanced solid-state NMR spectroscopy for the characterization of materials. In a DNP experiment the high polarization of unpaired electrons is transferred to magnetic nuclei. DNP represents a revolution for NMR spectroscopy since it can enhance the sensitivity of NMR experiments by several orders of magnitude. This enables NMR experiments previously considered impossible or infeasible and allows the application of NMR to previously intractable systems. For example, I have previously employed DNP enhanced solid-state NMR to improve the characterization of surfaces/interfaces of inorganic materials, observe dilute species and active sites, characterize the solid phases (polymorphs) of pharmaceuticals and to enable the fast acquisition of NMR spectra of unreceptive and challenging isotopes (e.g., 2H, 14N, 15N, etc.). However, there is much room for the improvement of DNP by developing sample preparation methods, theoretical models, optimizing polarizing agents, extending DNP to new classes of materials, etc. In collaboration with the Prof. Marek Pruski’s group we will utilize the state of the art 400 MHz/263 GHz DNP solid-state NMR spectrometer that was recently installed at the Ames Laboratory. In addition to work on DNP enhanced solid-state NMR we are also interested in developing and applying conventional high resolution solid-state NMR techniques. Students and researchers in my group will primarily work on the applications and/or development of NMR techniques. However, they also gain experience in basic synthetic and sample preparation techniques and other characterization and modeling techniques such as EPR spectroscopy, quantum chemical calculations, X-ray diffraction, etc.